Detalhe da pesquisa
1.
Predicting Tacrolimus Concentrations in the Skin of Adult Kidney Transplant Recipients: A Feasibility Study.
Transpl Int
; 37: 12019, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38323070
2.
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
J Enzyme Inhib Med Chem
; 39(1): 2313055, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38416868
3.
Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer.
Bioorg Med Chem Lett
; 29(2): 216-219, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503634
4.
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling.
Exp Cell Res
; 370(2): 283-291, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959912
5.
Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).
Bioorg Med Chem Lett
; 28(8): 1357-1362, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29545103
6.
Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6).
Bioorg Med Chem Lett
; 28(15): 2636-2640, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945795
7.
Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193668
8.
Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents.
Bioorg Med Chem Lett
; 27(4): 967-972, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082040
9.
Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.
Antimicrob Agents Chemother
; 60(5): 3076-89, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26953199
10.
A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo.
Pharmacol Res
; 113(Pt A): 533-546, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27687956
11.
Fluorescent Probes for H2S Detection and Quantification.
Handb Exp Pharmacol
; 230: 291-323, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26162841
12.
Structure and ligand-based design of mTOR and PI3-kinase inhibitors leading to the clinical candidates VS-5584 (SB2343) and SB2602.
J Chem Inf Model
; 54(11): 3238-50, 2014 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25317974
13.
SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis.
J Immunol
; 189(8): 4123-34, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22962687
14.
Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts.
J Immunother Cancer
; 11(9)2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37678918
15.
Structure-based design of PDK1 inhibitors.
Bioorg Med Chem Lett
; 22(1): 305-7, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119465
16.
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.
Bioorg Med Chem Lett
; 22(2): 1009-13, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197143
17.
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.
Bioorg Med Chem Lett
; 22(12): 4023-7, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22591730
18.
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Bioorg Med Chem Lett
; 22(8): 2880-4, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437109
19.
Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3).
J Comput Aided Mol Des
; 26(4): 437-50, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22527961
20.
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
Bioorg Med Chem Lett
; 19(3): 894-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19095445